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Biomarkers
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Bone Formation
OC (Osteocalcin) - ECL
Analyte:
Osteocalcin
Specimen Type:
Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance:
Osteocalcin, a 49 amino acid peptide is the major noncollagen protein of bone. It contains three gamma-carboxyglutamic acid (GLA) residues at positions 17, 21 and 24 and is, therefore, also known as bone gla-protein or BGP. The exact biological function of osteocalcin is not known but the three gamma-carboxyglutamic acid residues confer on it a…
OPG (Osteoprotegerin)
Analyte:
Osteoprotegerin
Specimen Type:
Serum, Inquire for additional option(s)
Biological or Clinical Significance:
Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues; it has a molecular weight of 60 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. OPG inhibits the change of RANK…
OPN (Osteopontin), Plasma
Analyte:
Osteopontin
Specimen Type:
EDTA Plasma
Biological or Clinical Significance:
Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Based on gene structure and chromosomal location, OPN is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that also…
OPN (Osteopontin), Urine
Analyte:
Osteopontin
Specimen Type:
Urine
Biological or Clinical Significance:
Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Based on gene structure and chromosomal location, OPN is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that also…
PINP (N-Terminal Propeptide of Type I Collagen) - RIA
Analyte:
Aminoterminal Propeptide of Type I Collagen
Specimen Type:
Serum
Biological or Clinical Significance:
Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix. During bone formation, collagen type I is synthesized from pro-collagen type I, which is secreted from fibroblasts and osteoblasts. Type I procollagen contains N- and C-terminal extensions which are removed by specific proteases during…