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Bone Formation

OC (Osteocalcin) - ECL

Analyte: Osteocalcin
Specimen Type: Serum, EDTA Plasma, Inquire for additional option(s)
Biological or Clinical Significance: Osteocalcin, a 49 amino acid peptide is the major noncollagen protein of bone. It contains three gamma-carboxyglutamic acid (GLA) residues at positions 17, 21 and 24 and is, therefore, also known as bone gla-protein or BGP. The exact biological function of osteocalcin is not known but the three gamma-carboxyglutamic acid residues confer on it a…

OPN (Osteopontin), Plasma

Analyte: Osteopontin
Specimen Type: EDTA Plasma
Biological or Clinical Significance: Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glycoprotein.  Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression.  Based on gene structure and chromosomal location, OPN is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that also…

OPN (Osteopontin), Urine

Analyte: Osteopontin
Specimen Type: Urine
Biological or Clinical Significance: Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glycoprotein.  Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression.  Based on gene structure and chromosomal location, OPN is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that also…

PINP (N-Terminal Propeptide of Type I Collagen) - RIA

Analyte: Aminoterminal Propeptide of Type I Collagen
Specimen Type: Serum
Biological or Clinical Significance: Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix.  During bone formation, collagen type I is synthesized from pro-collagen type I, which is secreted from fibroblasts and osteoblasts.  Type I procollagen contains N- and C-terminal extensions which are removed by specific proteases during…

Vitamin D, 1,25-(OH)2 (1.25 dihydroxy Vitamin D)

Analyte: Vitamin D, 1,25 - Dihydroxy
Specimen Type: Serum, Inquire for additional options(s)
Biological or Clinical Significance: Vitamin D, also known as caliciferal; is a group of fat-soluble secosteroids, the two major physiologically revlevant forms of which are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D without a subscript refers to either D2 or D3 or both. Vitamin D3 is derived mainly from actions of ultraviolet light on the skin while…
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