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Bone Resorption

DKK-1 (Dickkopf-Related Protein-1)

Analyte: -DKK 1
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Dickkopf related protein 1 (Dkk-1) was the first identified member of the Dickkopf family of secreted proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy.  Dickkopf (meaning “stubborn” or “thick headed”) was discovered as an inducer of head formation in Xenopus.  Dkk proteins contain two conserved cysteine-rich domains separated by a linker…

DPD Free (Deoxypyridinoline), Urine

Analyte: Deoxypyridinoline, free
Specimen Type: Urine (unpreserved 1st or 2nd void)
Biological or Clinical Significance: Approximately 90% of the organic matrix of bone is type I collagen, a triple helical protein.  Type I collagen of bone is crosslinked by specific molecules which provide rigidity and strength.  Crosslinks of mature type I collagen in bone are the pyridinium crosslinks, pyridinoline (PYD) and deoxypyridinoline (DPD).  DPD is formed by the enzymatic action…

PYD, Total (Pyridinoline)

Analyte: Pyridinoline
Specimen Type: Serum
Biological or Clinical Significance: The Serum PYD assay provides a quantitative measure of the excretion of pyridinoline crosslinks in serum. Structural collagens such as types I and II that are present in bone and cartilage, respectively, are crosslinked both within their a-chains and between adjacent molecules to provide rigidity and strength to the resulting collagen fibril. In bone and…

RANK-L (Receptor Activitor for Nuclear Factor B Ligand)

Analyte: RANK-L
Specimen Type: Serum
Biological or Clinical Significance: sRANKL, receptor activator of nuclear factor (NF)-κB ligand (also: osteoprotegerin ligand, OPGL), is a part of the TNF superfamily with high similarity to other members of that protein species. RANKL, RANK, and osteoprotegerin (OPG) have been identified as the key molecular regulation system for bone remodeling. RANKL is the main stimulatory factor for the formation…

SOST (Sclerostin)

Analyte: Sclerostin
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL
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