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Bone Resorption

DKK-1 (Dickkopf-Related Protein-1)

Analyte: -DKK 1
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Dickkopf related protein 1 (Dkk-1) was the first identified member of the Dickkopf family of secreted proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy.  Dickkopf (meaning “stubborn” or “thick headed”) was discovered as an inducer of head formation in Xenopus.  Dkk proteins contain two conserved cysteine-rich domains separated by a linker…

DPD Free (Deoxypyridinoline), Urine

Analyte: Deoxypyridinoline, free
Specimen Type: Urine (unpreserved 1st or 2nd void)
Biological or Clinical Significance: Approximately 90% of the organic matrix of bone is type I collagen, a triple helical protein.  Type I collagen of bone is crosslinked by specific molecules which provide rigidity and strength.  Crosslinks of mature type I collagen in bone are the pyridinium crosslinks, pyridinoline (PYD) and deoxypyridinoline (DPD).  DPD is formed by the enzymatic action…

NTx (N-Telopeptides of Type I Collagen), Urine

Analyte: N-Telopeptide Type I Collagen
Specimen Type: Urine (2nd morning void preferred; do not add preservative)
Biological or Clinical Significance: Bone resorption is a function of osteoclasts.  These cells remove the mineral from bone and break down the organic matrix that is primarily comprised of type I collagen.  Collagen is a cross-linked fibrous protein that forms the fabric of bone and most other connective tissues. Bone contains three polypeptide chains wound together in a helical…

PYD, Total (Pyridinoline)

Analyte: Pyridinoline
Specimen Type: Serum
Biological or Clinical Significance: The Serum PYD assay provides a quantitative measure of the excretion of pyridinoline crosslinks in serum. Structural collagens such as types I and II that are present in bone and cartilage, respectively, are crosslinked both within their a-chains and between adjacent molecules to provide rigidity and strength to the resulting collagen fibril. In bone and…

SOST (Sclerostin)

Analyte: Sclerostin
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL
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