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Cardiovascular
CXCL-12 SDF-1 (Stromal Cell Derived Factor-1)
Analyte:
Stromal Cell Derived Factor-1
Specimen Type:
PlatletPoor EDTA Plasma
Biological or Clinical Significance:
SDF-1 alpha or stromal derived factor 1 alpha (also known as CXCL12) has weak sequence homology with other CXC chemokines and with members of the CC (β) chemokines sub-family In contrast to other chemokines genes, which are on chromosomes 4 or 17, the SDF-1 gene is on chromosome 10. SDF-1 also has a higher degree…
Galectin-3
Analyte:
Galectin-3
Specimen Type:
Serum, Inquire for additional option(s)
Biological or Clinical Significance:
Galectin-3 is a structurally unique member of a family of beta-galactosidase-binding lectins. Expression of galectin-3 has been associated with the epithelium and inflammatory cells including macrophages, neutrophils and mast cells. Galectin-3 has been implicated in a variety of biological processes important in heart failure, including myofibroblast proliferation, fibrogenensis, tissue repair, cardiac remodeling and inflammation.
gp130 (Gycoprotein 130)
Analyte:
Gycoprotein 130
Specimen Type:
Serum, Inquire for addtional option(s)
Biological or Clinical Significance:
Interleukin 6 (IL-6) is a multifunctional protein that plays important roles in host defense, acute phase reactions, immune responses, and hematopoiesis. IL-6 exerts its activity through binding to a high affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa IL-6-binding receptor protein (IL-6R) and a 130kDa signal-transducing protein (gp130). Human gp130 consists of…
MCP-1 (Monocyte Chemotactic Protein-1) - chemi
Analyte:
Monocyte Chemotactic Protein-1
Specimen Type:
Serum
Biological or Clinical Significance:
Monocyte Chemotactic Protein-1 (MCP-1), also known as CCL2, MCAF and TDCF, is encoded by the human JE gene. It belongs to the CC chemokine family. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. Elevated levels of MCP-1 have also been found in connection with inflammation, Alzheimer’s…
SDF-1 (Stromal Cell Derived Factor-1) (CXCL-12)
Analyte:
Stromal Cell Derived Factor-1
Specimen Type:
Platelet Poor EDTA Plasma; please contact nexelis for collection information
Biological or Clinical Significance:
SDF-1 alpha or stromal derived factor 1 alpha (also known as CXCL12) has weak sequence homology with other CXC chemokines and with members of the CC (β) chemokines sub-family In contrast to other chemokines genes, which are on chromosomes 4 or 17, the SDF-1 gene is on chromosome 10. SDF-1 also has a higher degree…