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Coagulation

D-Dimer

Analyte: D-Dimer
Specimen Type: Citrate Plasma, Heparin Plasma, Inquire for additional option(s)
Biological or Clinical Significance: Before clot formation, prothrombin must be converted to thrombin. When the level thrombin exceeds the ability of antihrombin and other inhibitors to neutralize it fibrinopeptides are released from the soluble plasma protein, fibrinogen. Molecular polymerization occurs with the formation of soluble fibrin that is then stabilized with covalent cross-linking by FXIIIa activity to produce an…

Fibrinogen

Analyte: Fibrinogen
Specimen Type: EDTA Plasma (Preferred), Citrate Plasma (Acceptable)
Biological or Clinical Significance: Fibrinogen is a soluble precursor of the insoluble fibrin, the major component of blood clots. It is a 340,000 Dalton glycoprotein composed of six subunits. When fibrinogen is activated by the proteolytic enzyme thrombin, four subunits are removed. The remaining units polymerize into fibrin strands, which form the basic structure of a blood clot. About…

PAI -1 (Plasminogen Activator Inhibitor-1)

Analyte: Plasminogen Activator Inhibitor 1
Specimen Type: Frozen Citrate or EDTA Plasma
Biological or Clinical Significance: Plasminogen activator inhibitor-1 (PAI – 1) is the principal inhibitor of tissue plasminogen activator and urokinase, the activators of plaminogen and hence fibrinolysis. PAI-1 is present in increased levels in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome. It has been linked to…
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