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HDL Functionality

HDL-SAA (HDL Serum Amyloid A)

Analyte: HDL-Serum Amyloid A
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Serum Amyloid A (SAA) is an acute-phase protein. During acute events, the rise in SAA levels is one of the most rapid and intense increases of all acute phase proteins. When elevated above normal levels SAA is almost exclusively bound to High Density Lipoproteins (HDL). SAA circulates at trace levels (1-5 µg/mL) during normal conditions;…

LCAT Mass (Lecithin-Cholesterol Acyltransterase)

Analyte: Lecithin Cholesterol Acyltransferase Mass
Specimen Type: EDTA Plasma (recommended), Serum*
Biological or Clinical Significance: High density lipoprotein (HDL) plays an important role in reverse cholesterol transport, a process by which excess cholesterol from peripheral tissues is returned to the liver for use or excretion. There is a strong inverse correlation between plasma HDL cholesterol concentration and the incidence of atherosclerosis. Lecithin-cholesterol acyltransferase (LCAT) performs a central role in HDL…

Pre β1-HDL

Analyte: Pre ß1 High-Density Lipoprotein
Specimen Type: EDTA Plasma with stabilizer recommended; please contact nexelis for collection information
Biological or Clinical Significance: Pre β1-HDL is a discoid-shaped HDL particle of approximately 67 kDa that migrates with pre-β electrophoretic mobility on agarose gels. It contains apolipoprotein A-I (Apo AI), phospholipids and unesterified cholesterol. Pre β1-HDL removes cholesterol from peripheral tissues through the reverse cholesterol transport (RCT). Depletion of Pre β1-HDL results in reduced in vitro cholesterol efflux from…

sPLA2 Activity (Secretory Phopholipase Type A2)

Analyte: Secretory Phospholipase Type A2 Activity
Specimen Type: EDTA Plasma, Serum
Biological or Clinical Significance: The phospholipase A2 family of enzymes catalyse the hydrolysis of cellular phospholipids at the sn-2 position to release lysophospholipids and free fatty acids. Secretory type-IIa phospholipase (sPLA2) has also been reported to be an acute-phase reactant, so higher levels may follow the course of inflammatory diseases, like RA, for example. The involvement of type-IIa secretory…

sPLA2 Mass (Secretory Phopholipase Type A2)

Analyte: Secretory Phospholipase Type A2 Mass
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL
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