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Inflammation and Immunity

ICAM-1 (Intra-Cellular Adhesion Molecule-1) - Chemiluminescence

Analyte: Intra-Cellular Adhesion Molecule-1
Specimen Type: Serum
Biological or Clinical Significance: ICAM-1 (Intercellular Adhension Molecule 1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. It is a member of the immunoglobulin superfamily of adhension molecules.

IL-18 (Interleukin 18), Urine

Analyte: Interleukin-18
Specimen Type: Urine
Biological or Clinical Significance: Interleukin 18 (IL-18) is a 18kDa novel cytokine which is identified as a costimulatory factor for production of interferon-γ (IFN- γ) in response to toxic shock. It shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 β…

Procalcitonin

Analyte: Procalcitonin
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance: Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta signaling begins with binding to a TGF-beta RII and…

VCAM-1 (Vascular Adhesion Molecule-1) - Chemiluminescence

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance: VCAM-1 ( Vascular Cell Adhension Protein 1), also known as CD106, binds to leukocyte integrins VLA-4 and Integrin alpha 4 beta 7. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. It is a member  of the immunoglobulin superfamily of adhesion molecules. 
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