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Inflammation and Immunity

ICAM-1 (Intra-Cellular Adhesion Molecule-1) - Chemiluminescence

Analyte: Intra-Cellular Adhesion Molecule-1
Specimen Type: Serum
Biological or Clinical Significance: ICAM-1 (Intercellular Adhension Molecule 1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. It is a member of the immunoglobulin superfamily of adhension molecules.

IL-18 (Interleukin 18), Urine

Analyte: Interleukin-18
Specimen Type: Urine
Biological or Clinical Significance: Interleukin 18 (IL-18) is a 18kDa novel cytokine which is identified as a costimulatory factor for production of interferon-γ (IFN- γ) in response to toxic shock. It shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 β…

M-CSF-1 (Macrophage Colony Stimulating Factor)

Analyte: Macrophage Colony Stimulating Factor
Specimen Type: Serum, Lithium Heparin Plasma
Biological or Clinical Significance: M-CSF, also known as CSF-1, was originally discovered in serum, urine and other biological fluids as a factor that could stimulate the formation of macrophage colonies from bone marrow hematopoietic progenitor cells.  M-CSF can be produced by a number of cells, including fibroblasts, secretory epithelial cells of the endometrium, bone marrow stromal cells, brain astrocytes,…

Procalcitonin

Analyte: Procalcitonin
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL

VCAM-1 (Vascular Adhesion Molecule-1) - Chemiluminescence

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance: VCAM-1 ( Vascular Cell Adhension Protein 1), also known as CD106, binds to leukocyte integrins VLA-4 and Integrin alpha 4 beta 7. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. It is a member  of the immunoglobulin superfamily of adhesion molecules. 
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