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Inflammation and Immunity

ICAM-1 (Intra-Cellular Adhesion Molecule-1) - Chemiluminescence

Analyte: Intra-Cellular Adhesion Molecule-1
Specimen Type: Serum
Biological or Clinical Significance: ICAM-1 (Intercellular Adhension Molecule 1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. It is a member of the immunoglobulin superfamily of adhension molecules.

IL-6 sR (Interleukin 6 Soluble Receptor)

Analyte: Interleukin 6 soluble receptor
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Interleukin 6 (IL-6) is a multifunctional cytokine that has a major role in initiation and promulgation of the inflammatory and immune responses.  It is produced by a wide variety or cell types including T cells, monocyte/macrophages, fibroblasts, hepatocytes, vascular endothelial cells, cardiac myxomas, bladder cell carcinomas, myelomas, astrogliomas, and glioblastomas.  The effects of IL-6 on…

M-CSF-1 (Macrophage Colony Stimulating Factor)

Analyte: Macrophage Colony Stimulating Factor
Specimen Type: Serum, Lithium Heparin Plasma
Biological or Clinical Significance: M-CSF, also known as CSF-1, was originally discovered in serum, urine and other biological fluids as a factor that could stimulate the formation of macrophage colonies from bone marrow hematopoietic progenitor cells.  M-CSF can be produced by a number of cells, including fibroblasts, secretory epithelial cells of the endometrium, bone marrow stromal cells, brain astrocytes,…

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance: Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta signaling begins with binding to a TGF-beta RII and…

VCAM-1 (Vascular Adhesion Molecule-1) - Chemiluminescence

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance: VCAM-1 ( Vascular Cell Adhension Protein 1), also known as CD106, binds to leukocyte integrins VLA-4 and Integrin alpha 4 beta 7. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. It is a member  of the immunoglobulin superfamily of adhesion molecules. 
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