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Lipid Metabolism

LCAT Activity (Lecithin-Cholesterol Acyltransferase)

Analyte: Lecithin Cholesterol Acyltransferase Activity
Specimen Type: Serum,EDTA Plasma
Biological or Clinical Significance: Lecithin-cholesterol acyltransferase (LCAT) is a 63kDa glycoprotein synthesized in the liver, released into the circulation, and primarily activated by apo A-I. LCAT is an enzyme that catalyzes the formation of cholesteryl esters on HDL, particularly HDL3, and by that promotes maturation of HDL particles in plasma and facilitates reverse cholesterol transport by maintaining a concentration…

LCAT Mass (Lecithin-Cholesterol Acyltransterase)

Analyte: Lecithin Cholesterol Acyltransferase Mass
Specimen Type: EDTA Plasma (recommended), Serum*
Biological or Clinical Significance: High density lipoprotein (HDL) plays an important role in reverse cholesterol transport, a process by which excess cholesterol from peripheral tissues is returned to the liver for use or excretion. There is a strong inverse correlation between plasma HDL cholesterol concentration and the incidence of atherosclerosis. Lecithin-cholesterol acyltransferase (LCAT) performs a central role in HDL…

PCSK9 (Proprotein Convertase Subtilisin/Keexin Type 9)

Analyte: Proprotein Convertase Subtilisin/Keexin Type 9
Specimen Type: EDTA Plasma, Serum
Biological or Clinical Significance: Proprotein convertase subtilisin kexin 9 (PCSK9), also named neural apoptosis-regulated convertase 1 (NARC-1), is a member of the proteinase K subfamily of subtilisin-related serine endoproteases.  The full-length protein has 692 amino acids, including a signal peptide, a prodomain and a catalytic domain.  PCSK ( is highly expressed in the liver, intestine and kidney.  It is…

sPLA2 Activity (Secretory Phopholipase Type A2)

Analyte: Secretory Phospholipase Type A2 Activity
Specimen Type: EDTA Plasma, Serum
Biological or Clinical Significance: The phospholipase A2 family of enzymes catalyse the hydrolysis of cellular phospholipids at the sn-2 position to release lysophospholipids and free fatty acids. Secretory type-IIa phospholipase (sPLA2) has also been reported to be an acute-phase reactant, so higher levels may follow the course of inflammatory diseases, like RA, for example. The involvement of type-IIa secretory…

sPLA2 Mass (Secretory Phopholipase Type A2)

Analyte: Secretory Phospholipase Type A2 Mass
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL
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