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Lipoprotein Components

HDL Preβ-1 (HDL Prebeta 1)

Analyte: Pre ß1 High-Density Lipoprotein
Specimen Type: EDTA plasma with stabilizer recommended; please contact nexelis for collection information
Biological or Clinical Significance: Pre β1-HDL is a discoid-shaped HDL particle of approximately 67 kDa that migrates with pre-β electrophoretic mobility on agarose gels. It contains apolipoprotein A-I (Apo AI), phospholipids and unesterified cholesterol. Pre β1-HDL removes cholesterol from peripheral tissues through the reverse cholesterol transport (RCT). Depletion of Pre β1-HDL results in reduced in vitro cholesterol efflux from…

HDL-Apolipoproteins A-II

Analyte: HDL Apolipoproteins AII
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Apolipoproteins are the protein components of lipoproteins in plasma and determine the structure, function, and metabolism of lipoproteins. Apolipoprotein A-I and A-II constitute about 90% of the total HDL protein. The ratio of Apo A-I to Apo A-II in HDL is about 3:1. Apo A-I and Apo A-II modulate HDL metabolism. Apo A-I and Apo…

HDL-Apolipoproteins C-II

Analyte: HDL Apolipoproteins CII
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Apolipoproteins are components of lipoproteins in plasma and are important in determining the structure, function and metabolism of lipoproteins. Apolipoprotein C-II is contained in very low density lipoproteins (VLDL) and high density lipoproteins (HDL), and activates lipoprotein lipase (LPL) on the surface of endothelial cells. In type II dyslipidemia patients a strong positive correlation between…

HDL-Apolipoproteins C-III

Analyte: HDL Apolipoproteins CIII
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Apolipoprotein-lipid complexes are referred to as lipoproteins.  The apolipoproteins are plasma protein components that complex with cholesterol, cholesterol esters, glycerides (triglycerides, etc.) and phospholipids, as well as other lipid soluble substances, such as lipid-soluble vitamins, and facilitate their transport and metabolism.  Apolipoprotein C-III is an 8.8 kDa protein that appears to inhibit lipoprotein lipase (LPL)…

HDL-Apolipoproteins E

Analyte: HDL Apolipoproteins E
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: Apolipoprotein E is a 299 amino acid, arginine – rich glycoprotein. The major source of synthesis and secretion is liver parenchymal cells, which secrete Apo E in association with VLDL particles. Apo E is also a protein component of several other classes of plasma lipoproteins, including chylomicrons, chylomicron remnants, IDL and HDL. Only a minute…
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