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Liver Injury

CTGF (Connective Tissue Growth Factor)

Analyte: Connective Tissue Growth Factor
Specimen Type: Serum
Biological or Clinical Significance: CTGF, a member of the CCN protein family, is relevant in many physiological and pathological processes.  Both clinical and experimental studies have demonstrated that CTGF is overexpressed in fibrotic human liver and in experimental animal models of liver fibrogenesis.  CTGF is detectable in various human fluids (serum, plasma, and urine) and can potentially provide information…

FAS (APO1) (CD95)

Analyte: FAS
Specimen Type: Serum, EDTA Plasma
Biological or Clinical Significance: Fas (APO-1 or CD95) is a cell-surface receptor that transduces apoptotic signals from Fas ligand (FasL).  It is a glycoprotein with a mass estimated at 43 to 48 kDa.  Fas is a member of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), and it shares a cytoplasmic motif with TNF RI, referred to as the ‘death…

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance: Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta signaling begins with binding to a TGF-beta RII and…

TGF ß-1 (Transforming Growth Factor ß-1), Urine

Analyte: Transforming Growth Factor ß-1
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL

Type IV Collagen

Analyte: Type IV Collagen
Specimen Type: Serum
Biological or Clinical Significance: Chronic liver disease comprises a number of progressive disorders which culminate in liver cirrhosis and which are characterized by excessive deposition of collagen. Although various types of collagen (type I, III, IV, V and VI) increase in the liver with the progression of fibrosis, type IV collagen, a constituent of the basement membrane, is particularly…
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