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Oncology

April (A Proliferation-inducing Ligand)

Analyte: A Proliferation-Inducing Ligand
Specimen Type: Serum
Biological or Clinical Significance: APRIL (A PRoliferation-Inducing Ligand) is a member of the tumor necrosis factor family. APRIL shows high levels of expression in tumors of different origin and low level of expression in normal cells. APRIL shares two TNF receptor family members, TACI and BCMA with another TNF homolog, BlyS/BAFF both of which have been reported to play…

BCMA (B-cell Maturation Antigen)

Analyte: B-cell Maturation Antigen
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: BCMA, B cell maturation antigen, is a member of the TNF receptor superfamily.  It has been designated TNFRSF17.  BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of…

IL-18 (Interleukin 18), Urine

Analyte: Interleukin-18
Specimen Type: Urine
Biological or Clinical Significance: Interleukin 18 (IL-18) is a 18kDa novel cytokine which is identified as a costimulatory factor for production of interferon-γ (IFN- γ) in response to toxic shock. It shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 β…

M-CSF-1 (Macrophage Colony Stimulating Factor)

Analyte: Macrophage Colony Stimulating Factor
Specimen Type: Serum, Lithium Heparin Plasma
Biological or Clinical Significance: M-CSF, also known as CSF-1, was originally discovered in serum, urine and other biological fluids as a factor that could stimulate the formation of macrophage colonies from bone marrow hematopoietic progenitor cells.  M-CSF can be produced by a number of cells, including fibroblasts, secretory epithelial cells of the endometrium, bone marrow stromal cells, brain astrocytes,…

VCAM-1 (Vascular Adhesion Molecule-1) - Chemiluminescence

Analyte: Vasclular Endothelial Growth Factor-D
Specimen Type: Serum
Biological or Clinical Significance: VCAM-1 ( Vascular Cell Adhension Protein 1), also known as CD106, binds to leukocyte integrins VLA-4 and Integrin alpha 4 beta 7. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. It is a member  of the immunoglobulin superfamily of adhesion molecules. 
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