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Oncology

April (A Proliferation-inducing Ligand)

Analyte: A Proliferation-Inducing Ligand
Specimen Type: Serum
Biological or Clinical Significance: APRIL (A PRoliferation-Inducing Ligand) is a member of the tumor necrosis factor family. APRIL shows high levels of expression in tumors of different origin and low level of expression in normal cells. APRIL shares two TNF receptor family members, TACI and BCMA with another TNF homolog, BlyS/BAFF both of which have been reported to play…

BCMA (B-cell Maturation Antigen)

Analyte: B-cell Maturation Antigen
Specimen Type: Serum, Inquire for additional option(s)
Biological or Clinical Significance: BCMA, B cell maturation antigen, is a member of the TNF receptor superfamily.  It has been designated TNFRSF17.  BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of…

CA 9 (Carbonic Anhydrase IX)

Analyte: Carbonic Anhydrase IX
Specimen Type: Serum
Biological or Clinical Significance: Carbonic anhydrase IX (CA9, also known as membrane antigen MN) is a member of the carbonic anhydrase protein family.  It is a transmembrane protein that consists of an N-terminal signal peptide, an extracellular proteoglycan-related domain and catalytic domain, a transmembrane segment, and a C-terminal intracellular tail.  The major physiologic function for CA9 is to regulate…

IL-8 (Interleukin-8)

Analyte: Interleukin-8
Specimen Type: Serum
Biological or Clinical Significance: Interleukin 8 (IL-8) or CXCL8 is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. IL-8 is also…

VEGF-A (Vasclular Endothelial Growth Factor-A)

Analyte: Vasclular Endothelial Growth Factor-A
Specimen Type: Serum
Biological or Clinical Significance: Vascular endothelial growth factor A is a protein that in humans is encoded by the VEGF-A gene. It is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. VEGF-A plays important roles in inflammation and during normal and pathological angiogenesis. Elevated levels of VEGF have been reported in synovial…
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