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Pulmonary

CTGF (Connective Tissue Growth Factor)

Analyte: Connective Tissue Growth Factor
Specimen Type: Serum
Biological or Clinical Significance: CTGF, a member of the CCN protein family, is relevant in many physiological and pathological processes.  Both clinical and experimental studies have demonstrated that CTGF is overexpressed in fibrotic human liver and in experimental animal models of liver fibrogenesis.  CTGF is detectable in various human fluids (serum, plasma, and urine) and can potentially provide information…

Surfactant Protein D

Analyte: Surfactant Protein D
Specimen Type: Heparin plasma
Biological or Clinical Significance: Human surfactant protein D (SP-D) is a member of the collageneous subfamily of glycoproteins and calcium-dependent lectins (collectins). SP-D is a homotrimeric protein consisting of three 43kDa units that are bonded at their N-termini.  Most preparations of SP-D contain predominantly dodecamers (four trimeric subunits), but higher multimers also have been observed.  Each unit consists of…

Tenascin C

Analyte: Tenascin C
Specimen Type: EDTA Plasma
Biological or Clinical Significance: Tenascin-C is an extracellular matrix glycoprotein that is composed of 210-400 kDa subunits consisting of four domains.  One subunit has a TA domain at the N-terminal end, then an epidermal growth factor-like sequence domain (EGF-like domain), a fibronectin type III (FN III) repeat domain, and a fibrinogen-like domain at the C-terminal end.  There is an…

TGF ß-1 (Transforming Growth Factor ß-1) - Chemi.

Analyte: Transforming Growth Factor ß-1
Specimen Type: Serum
Biological or Clinical Significance: Transforming Growth Factor Beta 1(TGF-Beta1), is encoded by the human TGF-Beta gene. It a polypeptide member of the transtroming growth factor beta superfamily and cytokines. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta signaling begins with binding to a TGF-beta RII and…

TGF ß-1 (Transforming Growth Factor ß-1), Urine

Analyte: Transforming Growth Factor ß-1
Specimen Type: For information on this assay, please contact nexelis.
Biological or Clinical Significance: NULL
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