Neomed Labs Pacific Biomarkers PAIRimmune are now Nexelis
 

search & filter

Our assay menus are offered in both alphabetical and category-based formats.

search by:

or filter by:

IL-17F (Interleukin-17F), ultrasensitive

Analyte: Interleukin-17F
Specimen Type: EDTA Plasma
Optimum Volume: 0.5 mL
2-8°C -20°C -70°C
3 days TBD TBD
Reporting units: pg/mL
Method: Fluorescent Immunoassay
Biological or Clinical Significance:

The IL-17F gene was discovered in 2001, and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo, and has been shown to have a pro-inflammatory role in asthma. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors, and activates the MAP kinase related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation, and have important therapeutic implications in asthma.

Principle of Test Method:

The IL-17A immunoassay is a quantitative fluorescent sandwich immunoassay designed to measure IL-17A in human serum or EDTA plasma samples. The detection system employs a single molecule counting (SMC™) technique that enables ultrasensitive biomarker measurement.

Download this assay page in pdf format.

IL-17F (Interleukin-17F), ultrasensitive
back to top