Neomed Labs Pacific Biomarkers PAIRimmune are now Nexelis

search & filter

Our assay menus are offered in both alphabetical and category-based formats.

search by:

or filter by:

KIM-1 (Kidney Injury Molecule-1), Urine

Analyte: Kidney Injury Molecule 1
Specimen Type: Urine (first morning void with stabilizer(s) recommended); Please contact nexelis for collection instructions
Optimum Volume: 2 mL
2-8°C -20°C -70°C
6 days** N.A.* N.A.*
Reporting units: pg/mL; ng/mg creatinine (normalized)
Method: ELISA
Biological or Clinical Significance:

Acute kidney injury has been defined as a rapid decline in glomerular filtration rate. Blood urea nitrogen and serum creatinine are not specific or sensitive enough for the diagnosis of acute kidney injury because they are affected by many renal and non-renal (age, sex, race, muscle mass, nutritional status, infection) factors that are independent of kidney injury or kidney function. Kidney injury molecule-1 (KIM-1) is a recently discovered biomarker that appears to overcome some of the shortcomings associated with BUN and serum creatinine. KIM-1 is a type I transmembrane glycoprotein. It is undetectable in healthy kidney tissue, but expressed at very high levels in proximal tubule epithelial cells in human kidneys after ischemic or toxic injury.

Principle of Test Method:

The KIM-1 assay is solid-phase ELISA that employs the quantitative sandwich enzyme immunoassay technique. KIM-1 is reported as a normalized ratio to urinary creatinine in order to account for variations in urine flow rate. Therefore KIM-1 and urine creatinine are preferably tested from the same aliquot.

*Please contact nexelis for stability information.

**Note: Refrigerated stability for stabilized urine is 6 days,  for non-stabilized urine 3 days.

Download this assay page in pdf format.

KIM-1 (Kidney Injury Molecule-1), Urine
back to top
contact us now

contact us

  • This field is for validation purposes and should be left unchanged.