Neomed Labs Pacific Biomarkers PAIRimmune are now Nexelis

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Pre β1-HDL

Analyte: Pre ß1 High-Density Lipoprotein
Specimen Type: EDTA Plasma with stabilizer recommended; please contact nexelis for collection information
Optimum Volume: 2.0 mL
2-8°C -20°C -70°C
5 days N.A. 1 year
Reporting units: ug/mL
Method: ELISA
Biological or Clinical Significance:

Pre β1-HDL is a discoid-shaped HDL particle of approximately 67 kDa that migrates with pre-β electrophoretic mobility on agarose gels. It contains apolipoprotein A-I (Apo AI), phospholipids and unesterified cholesterol. Pre β1-HDL removes cholesterol from peripheral tissues through the reverse cholesterol transport (RCT). Depletion of Pre β1-HDL results in reduced in vitro cholesterol efflux from fibroblasts.

The concentration of Pre β1-HDL in plasma is a reflection of the rate of its formation (result of cholesterol efflux and lipolysis of triglyceride-rich lipoproteins) and remodeling (through the action of LCAT). Thus, the level of Pre β1-HDL could reflect the sum of both of these steps.

Principle of Test Method:

The Pre β1-HDL assay is a sandwich ELISA.

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Pre β1-HDL
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