Neomed Labs Pacific Biomarkers PAIRimmune are now Nexelis

search & filter

Our assay menus are offered in both alphabetical and category-based formats.

search by:

or filter by:

Tenascin C

Analyte: Tenascin C
Specimen Type: EDTA Plasma
Optimum Volume: 0.5 mL
2-8°C -20°C -70°C
4 days 21 days 2 years
Reporting units: ng/mL
Method: ELISA
Biological or Clinical Significance:

Tenascin-C is an extracellular matrix glycoprotein that is composed of 210-400 kDa subunits consisting of four domains.  One subunit has a TA domain at the N-terminal end, then an epidermal growth factor-like sequence domain (EGF-like domain), a fibronectin type III (FN III) repeat domain, and a fibrinogen-like domain at the C-terminal end.  There is an alternatively spliced domain in the FN III domain, and it generates some types of variants of tenascin-C.  The subunits form a trimer by twisting at the N-terminal coiled domain and form a hexamer by a disulfide bond, in tissue.  While low molecular weight variants of tenascin-C are present in normal tissue, it is said that high molecular weight variants of tenascin-C are expressed in various diseased tissue including cancer.

Principle of Test Method:

The tenascin C assay is a solid phase sandwich ELISA.

  1. Hsia HC, Schwarzbauer JE. Meet the tenascins: multifunctional and mysterious. J Biol Chem. 2005; 280:26641-26644.

Download this assay page in pdf format.

Tenascin C
back to top
contact us now

contact us

  • This field is for validation purposes and should be left unchanged.