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Type IV Collagen
|1 wk||1 year||3 years|
Chronic liver disease comprises a number of progressive disorders which culminate in liver cirrhosis and which are characterized by excessive deposition of collagen. Although various types of collagen (type I, III, IV, V and VI) increase in the liver with the progression of fibrosis, type IV collagen, a constituent of the basement membrane, is particularly noteworthy for the following reasons: its serum level correlates with hepatic levels of type IV collagen, serum levels of type IV collagen fall in response to effective therapy and it is the earliest type of collagen to be synthesized during experimental liver injury. Serum type IV collagen levels are elevated in a variety of liver diseases, in particular, serum collagen levels have been found to be predictive of therapy response in Hepatitis C infection, and to be sensitive indicators of therapy response in abstaining alcoholics.