Neomed Labs Pacific Biomarkers PAIRimmune are now Nexelis

search & filter

Our assay menus are offered in both alphabetical and category-based formats.

search by:

or filter by:

Type IV Collagen

Analyte: Type IV Collagen
Specimen Type: Serum
Optimum Volume: 0.5 mL
2-8°C -20°C -70°C
1 wk 1 year 3 years
Reporting units: ng/mL
Method: ELISA
Biological or Clinical Significance:

Chronic liver disease comprises a number of progressive disorders which culminate in liver cirrhosis and which are characterized by excessive deposition of collagen. Although various types of collagen (type I, III, IV, V and VI) increase in the liver with the progression of fibrosis, type IV collagen, a constituent of the basement membrane, is particularly noteworthy for the following reasons: its serum level correlates with hepatic levels of type IV collagen, serum levels of type IV collagen fall in response to effective therapy and it is the earliest type of collagen to be synthesized during experimental liver injury. Serum type IV collagen levels are elevated in a variety of liver diseases, in particular, serum collagen levels have been found to be predictive of therapy response in Hepatitis C infection, and to be sensitive indicators of therapy response in abstaining alcoholics.

Principle of Test Method: The Type IV Collagen assay is a solid phase one-step sandwich EIA.

Download this assay page in pdf format.

Type IV Collagen
back to top
contact us now

contact us

  • This field is for validation purposes and should be left unchanged.