Biological or Clinical Significance:
Lipoprotein (a) [Lp(a)] was discovered as a genetic variant in low density lipoproteins (LDL) in 1963 by Berg (see reference 1). Lp(a) is a lipoprotein whose protein moiety is comprised of two major apolipoproteins, apolipoprotein B-100 (apo B100) and a protein which has not been found in any other lipoprotein and is responsible for unique characteristics of Lp(a), called apolipoprotein(a) [apo(a)]. One molecule of apo B-100 in Lp(a) is covalently linked to apo(a) by a disulfide bond. The analysis of the apo(a) cDNA led to the discovery that apo(a) has a high degree of homology with plasminogen. Components of Lp(a) have similarities to both LDL and plasminogen, suggesting that Lp(a) may represent a bridge between the fields of atherosclerosis and thrombosis. Numerous studies suggested an association of plasma Lp(a) concentrations with atherosclerotic vascular disease.
Principle of Test Method:
The Lp(a) assay is an automated immuoturbidimetric method.