Biological or Clinical Significance:
Glucagon-like peptide 1 (GLP-1) is a 3.5 kD incretin hormone secreted primarily from the enteroglucagon-producing L-cells in the small intestine. It is released in response to a meal and is highly potent in stimulating insulin and inhibiting glucagons secretion. GLP-1 (7-36) amide and GLP-1 (7-37) are the biologically active forms of GLP-1. In vivo, the active forms are rapidly degraded by the dipeptidyl peptidase IV (DPP-IV).
Principle of Test Method:
The GLP-1 total asay is an ultra-sensitive kit designed to quantify human total GLP-1 in human plasma, serum, and other biological media. This immunoassay employs electrochemilunimescent detection.