Biological or Clinical Significance:
Proglucagon gene is expressed in both pancreatic A cell and intestinal L cell. Tissue-specific posttranslational processing of proglucagon by prohormone convertase produces different proglucagon derived peptides (PGDPs) in both pancreas and intestine. The most notable PGDP is glucagon, whereas intestinal L cell produces several structurally related peptides, including glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), as well as glicentin and oxyntomodulin, which contain glucagon sequence in their molecules. Among PGDPs, GLP-2 has been found to show intestinal epithelial proliferation.
Principle of Test Method:
The ELISA kit for determination of human GLP-2 in plasma and serum samples is a competitive enzyme immunoassay.