Biological or Clinical Significance:
ICAM-1 (Intercellular Adhension Molecule 1), also known as CD54, binds the leukocyte integrins LFA-1 and Mac-1. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. It is a member of the immunoglobulin superfamily of adhension molecules.
Principle of Test Method:
The ICAM-1 assay is a chemiluminescent immunoassay. Assay Range: 7.8 – 8,000 pg/mL.