Biological or Clinical Significance:
Interleukin-17 (IL-17), originally identified as mouse cytotoxic T lymphocyte-associated antigen-8 (CTLA-8), is produced by activated T lymphocytes, primarily by memory T cells. IL-17 is the founding member of a cytokine family (also called IL-17A), and appears to mediate communication between the immune system and the hematopoietic system. IL-17 is a disulfide-linked homodimer.
IL-17 mediation of T cell communication with the hematopoietic system is suggested by two observations. T cell-derived IL-17 induces fibroblasts to produce IL-6, IL-8, ICAM-1 and G-CSF, apparently by an NF-κB-mediated mechanism. IL-6 in turn promotes development of granulocyte/macrophage colonies, and G-CSF directs development of neutrophils. IL-17 also enhances proliferation of partially activated T cells and upregulates nitric oxide (NO) production in osteoarthritic cartilage.
Principle of Test Method:
The IL-17 assay is a sandwich immunoassay using electrochemiluminescent detection.