IL-17A (Interleukin-17A), ultrasensitive

Analyte: Interleukin-17A
Specimen Type: EDTA Plasma
Optimum Volume: 0.5 mL
Reporting Units: pg/mL
Method: Fluorescent Immunoassay
2-8°C 1 day
-20°C TBD
-70°C TBD

Biological or Clinical Significance:

Interleukin17A (IL-17A) is the founding member of a group of cytokines called the IL-17 family.  There are several members of the IL-17 family, from IL-17A to IL-17F (IL-17E is also called IL-25). 

IL-17A is involved in mediating pro-inflammatory responses by inducing the production of many other cytokines, chemokines, and prostaglandins from many cell types.  The increased expression of chemokines attracts other cells, including neutrophils.  IL-17A has many physiological functions, such as airway remodeling.  As a result of these roles, the IL-17 family has been linked to many immune/autoimmune related diseases, including rheumatoid arthritis (RA), asthma, allergic responses, lupus, allograft rejections and anti-inflammatory immunity.

Principle of Test Method:

The IL-17A immunoassay is a quantitative fluorescent sandwich immunoassay designed to measure IL-17A in human serum or EDTA plasma samples. The detection system employs a single molecule counting (SMC™) technique that enables ultrasensitive biomarker measurement.