Biological or Clinical Significance:
Interleukin17A (IL-17A) is the founding member of a group of cytokines called the IL-17 family. There are several members of the IL-17 family, from IL-17A to IL-17F (IL-17E is also called IL-25).
IL-17A is involved in mediating pro-inflammatory responses by inducing the production of many other cytokines, chemokines, and prostaglandins from many cell types. The increased expression of chemokines attracts other cells, including neutrophils. IL-17A has many physiological functions, such as airway remodeling. As a result of these roles, the IL-17 family has been linked to many immune/autoimmune related diseases, including rheumatoid arthritis (RA), asthma, allergic responses, lupus, allograft rejections and anti-inflammatory immunity.
Principle of Test Method:
The IL-17A immunoassay is a quantitative fluorescent sandwich immunoassay designed to measure IL-17A in human serum or EDTA plasma samples. The detection system employs a single molecule counting (SMC™) technique that enables ultrasensitive biomarker measurement.