MCP-1 (Monocyte Chemotactic Protein-1) – chemi

Analyte: Monocyte Chemotactic Protein-1
Specimen Type: Serum
Optimum Volume: 0.4 mL
Reporting Units: pg/mL
Method: Chemiluminescence
2-8°C 3 days
-20°C 6 months
-70°C 6 months

Biological or Clinical Significance:

Monocyte Chemotactic Protein-1 (MCP-1), also known as CCL2, MCAF and TDCF, is encoded by the human JE gene. It belongs to the CC chemokine family. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. Elevated levels of MCP-1 have also been found in connection with inflammation, Alzheimer’s disease , myocardial ischemia, and viral infections. There are three G-protein-coupled receptors for MCP-1: CCR2, CCR4 and D6/CCBP2 (1, 20-22).

Principle of Test Method:

The MCP-1 assay is a chemiluminescent immunoassay. Detection range 0.8 – 800  MRD 1:25