Custom Protein Services for Drug Discovery and Life Sciences
All projects begin with the analysis of physico-chemical and biological properties of a target protein resulting in the development of tailored procedures for its extraction, purification, and characterization.
Molecular Biology
Our comprehensive services include molecular synthesis, cloning, and modification. To address your protein’s critical quality characteristics, we engage in rational design.
| Rational Design for Critical Quality Attributes | |
Purpose | Plan |
| Protein structure characterization | Apply bioinformatics |
| Alleviate solubility and expression challenges | Evaluate fusion partners |
| Improve protein homogeneity | Optimize post-translational modifications (PTM) |
| Promote expression | Harmonize RNA and DNA elements |
| Increase stability | Modify protease-susceptible sites |
| Our molecular biology services include: |
| Gene synthesis & sequencing |
| Molecular cloning protocol |
| Mutagenesis |
| DNA plasmid production |
| Other molecular biology assays (QPCR, RT-PCR, RNA, etc.) |
Protein Expression
We provide multiple expression systems to produce recombinant proteins. Our protein design and expression optimization services facilitate the generation of well-characterized products. Early on, we aim to ensure:
- Your preclinical product will be ready for scale-up
- Your reagents are well-suited for biological assays
- We are generating and selecting stable cell lines
- Your biologics process will be feasible at a commercial scale
Protein Purification
To purify your proteins, we design product-specific purification strategies to reach the desired purity and key parameters. We work on a wide range of purification methods or improve upon existing purification protocols, when necessary.
Protein Structure Characterization
Proper characterization of your protein’s biophysical properties mitigates risk. Orthogonal evaluation of key parameters, such as size in solution, folding, and sequence integrity ensures quality and consistency of delivered material.
Analytical Methods
Our protein science services encompass a range of analytical methods utilizing multiple assays that can be used to characterize a broad range of proteins expressed and purified by various methods.