TRACP-5b (Tartrate-Resistant Acid Phosphatase-5b)

Analyte: Tartrate-resistant acid phosphatase-5b
Specimen Type: Serum, Inquire for additional option(s)
Optimum Volume: 0.5 mL
Reporting Units: U/L
Method: ELISA
2-8°C 1 day
-20°C 2 months
-70°C 1 year

Biological or Clinical Significance:

Tartrate-resistant acid phosphatase (TRACP) is expressed in bone-resorbing osteoclasts and secreted into the circulation. Thus, serum TRACP has been considered as a potentially useful marker of bone resorption rate.

BoneTRAP® is specific for circulating osteoclast-derived TRACP-5b. BoneTRAP® detects only the active TRACP molecules that are freshly liberated in the circulation. It does not detect old circulating inactive TRACP molecules or fragments. Thus, BoneTRAP® gives an accurate estimation of the amount of bone resorption rate at the time of sample taking.

Principle of Test Method:

The TRACP-5b assay is a solid-phase ELISA designed to measure human TRACP-5b in serum or plasma. It is an immunofixed enzyme activity assay.