Immunogenicity Assessment: In Vitro Assays and Computational Analysis

ImmunXperts, a Q² Solutions company, provides trusted immunogenicity risk assessment services, including in vitro methods with T-cell proliferation as surrogate to measure the immunogenic potential for drug candidates, in silico methods for rapid, low-cost assessment of large number of lead candidates, MHC-associated peptide proteomics (MAPPS), and anti-drug antibody (ADA) assays. ImmunXperts also performs functional screening assays for immuno-oncology candidates and risk assessment and mitigation of drug candidates’ immunogenicity profiles. ImmunXperts is a trusted leader in supporting immuno-oncology drug discovery.

In Silico

Computer-based tools for profiling and lead optimization allow fast, sequence-based, early-stage modeling to assess immunogenicity in large numbers of lead candidates. We use state-of-the-art, well-documented, and benchmarked immunological bioinformatics tools for algorithmic evaluation. These advanced tools, which are constantly being optimized by Prof. Morton Nielsen’s lab at the Technical University of Denmark, are ideal for:

• T-cell epitope prediction
• Immunogenicity risk assessment
• Deimmunization
• Customization